Antiallergic substance from Asarum sagittarioides and synthesis of some analogues.
نویسندگان
چکیده
The MeOH extract of Asarum sagittarioides (Aristolochiaceae) showed antihistaminic activity. N-Isobutyl-3,4-methylenedioxybenzamide (1) was isolated as the active principle, and this compound was proved to be an antiallergic substance by pharmacological studies. Furthermore, in order to investigate the structure-activity relationships, some analogues of 1 were synthesized, and compounds 4 and 5 were found to show more potent activity than 1. Keywords-benzamide; Asarum sagittarioides; Aristolochiaceae; antihistamine; antiallergic activity
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 35 6 شماره
صفحات -
تاریخ انتشار 1987